What is the clinical evidence from this study?

Study design: Cohort. Population: Post-operative sepsis (n=229918). Intervention: Time period (2009) vs. Time period (2002). Primary outcome: Incidence rate of post-operative sepsis (per 1000 admissions) (RR 1.23, 95% CI 1.06-1.42, p=<0.01).

March 1, 2016Critical Care and ResuscitationOpen Access

Incidence and mortality of post-operative sepsis in New South Wales, Australia, 2002–2009

Q: What are the key findings of this study?

Between 2002 and 2009, the incidence of post-operative sepsis increased from 12.7 to 15.8 per 1000 admissions (RR 1.23), while sepsis-related mortality decreased from 26.9% to 20.2%.

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Key result

Post-operative sepsis incidence rose ~23% between 2002 and 2009 despite declining related mortality.

RR 1.23
95% CI 1.06-1.42
P<0.01
n=229,918

Population

229,918 adult elective surgical admissions in 82 public acute care hospitals in New South Wales, Australia…

Design

Cohort

Follow-up

In-hospital (during hospitalisation)

Authors

LOLixin OuSanming University JCJack ChenFrederick National Laboratory for Cancer Research TBTony BurrellNational Renewable Energy Laboratory

Discussion

Member takes

Implication

Postoperative sepsis mortality declined 2002-2009; hypothesis-generating for drivers of survival trends in elective surgery.

Study Design

Type

Cohort (n=229,918)

Multicenter

Yes

Structured PICO

Population

229,918 adult elective surgical patients aged 18 years or older with a length of stay >3 days, admitted to 82 public acute care hospitals in New South Wales between 2002 and 2009.

Outcome

Changes in the incidence rate of post-operative sepsis and sepsis-related mortalityhard clinical

Main Result

Relative Risk: 1.23 (95% CI 1.06–1.42)

Absolute Event Rate: 15.8% vs 12.7%

p-value: p=<0.01

Despite improvements in the case fatality rate of post-operative sepsis, the overall population incidence of sepsis-related deaths remained unchanged due to a rising incidence of post-operative sepsis, particularly from unspecified organisms.

Limitations

Results based on NSW acute care hospital surgical patient data may not be generalisable to other settings
Absolute accuracy of data extraction by professional coders cannot be guaranteed
True incidence of post-operative sepsis may have been underestimated because it can occur after hospital discharge
Results were based on NSW acute care hospital surgical patient data and may not be generalisable to other settings
Studied the period 2002-2009 specifically
Absolute accuracy of coding data extraction cannot be guaranteed
Post-operative sepsis after hospital discharge may have been missed, potentially underestimating the true incidence

Cite This Study

Ou et al. (2016) conducted a cohort in Post-operative sepsis (n=229,918). Time period (2009) vs. Time period (2002) was evaluated on Incidence rate of post-operative sepsis (per 1000 admissions) (RR 1.23, 95% CI 1.06-1.42, p=<0.01). Between 2002 and 2009, the incidence of post-operative sepsis increased from 12.7 to 15.8 per 1000 admissions (RR 1.23), while sepsis-related mortality decreased from 26.9% to 20.2%.

synapsesocial.com/papers/6aa0bce9511976e53f997684 https://doi.org/10.1016/s1441-2772(23)00937-7

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Incidence and mortality of post-operative sepsis in New South Wales, Australia, 2002–2009

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Incidence and mortality of post-operative sepsis in New South Wales, Australia, 2002–2009

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider