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October 1, 2015Chemistry Letters

Chemical Modification of Lipase for Rational Enhancement of Enantioselectivity

Tadashi Ema Hiroki Inoue

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Abstract

Chemical modifications of the I287C mutant of a Burkholderia cepacia lipase afforded various I287C-X conjugates, among which I287C-PAA bearing an N-phenylacetamide (PAA) moiety showed excellent enantioselectivity and catalytic activity for secondary alcohols. Site-directed chemical modifications are powerful tools to control enantioselective biocatalysis.

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Ema et al. (2015) studied this question.

synapsesocial.com/papers/6aa0bd8a511976e53f997695 https://doi.org/10.1246/cl.150667

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