Key result
Atorvastatin decreased FTO expression in endothelial cells, and FTO knockdown enhanced KLF2 and eNOS expression while attenuating TNFα-induced VCAM-1 and ICAM-1 expression.
Why the study?
Although m6A plays a critical role in various biological processes, no study had addressed the role of m6A modification in the statin-induced protection of endothelial cells.
Population
Endothelial cells
Comparison
Atorvastatin treatment and FTO gain- and loss-of-function assays vs controls
Design
In vitro preclinical laboratory study
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Does not alter statin use; leaves open m6A as a novel endothelial protection target.
FTO acts as a novel mediator of statin-induced endothelial protection by regulating KLF2 and eNOS expression in an m6A-dependent manner.
A 2022 study studied vascular diseases. Atorvastatin and FTO modulation was evaluated on Expression of FTO, KLF2, eNOS, VCAM-1, and ICAM-1. Atorvastatin decreased FTO expression in endothelial cells, and FTO knockdown enhanced KLF2 and eNOS expression while attenuating TNFα-induced VCAM-1 and ICAM-1 expression.
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