Key result
Concurrent nifedipine therapy significantly suppressed dose-related increases in quinidine serum concentrations.
Why the study?
Does concurrent nifedipine therapy alter quinidine serum concentrations in patients receiving quinidine?
Does concurrent nifedipine therapy alter quinidine serum concentrations in patients receiving quinidine?
Concurrent nifedipine therapy can suppress quinidine serum concentrations, requiring clinical vigilance when co-administering these drugs.
May warrant quinidine level monitoring with nifedipine co-administration; hypothesis-generating and requires validation in controlled studies.
Quinidine pharmacokinetics are known to be altered by a number of drugs. We present a case where dose-related increases in quinidine serum concentrations were significantly suppressed by concurrent nifedipine therapy. Clinicians should be alert to the possibility of an alteration in quinidine serum concentrations when instituting or discontinuing nifedipine in patients receiving quinidine.
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Lith et al. (1985) studied this question. Concurrent nifedipine therapy significantly suppressed dose-related increases in quinidine serum concentrations.
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