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March 28, 1974New England Journal of Medicine

Quinidine Elimination in Patients with Congestive Heart Failure or Poor Renal Function

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Why the study?

Does congestive heart failure or poor renal function alter the elimination of quinidine?

Population

Patients with poor renal function, congestive heart failure, and controls for half-life determination…

Comparison

Quinidine vs Controls (for the half-life determination group)

Design

Cohort

Authors

KKKenneth M. KesslerUniversity of MiamiDLDavid LöwenthalRutgers, The State University of New JerseyHWHoward WarnerCornell University

Discussion

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Implication

Quinidine half-life similar in heart failure or renal impairment; leaves open whether dosing adjustments are needed.

Structured PICO

Does congestive heart failure or poor renal function alter the elimination of quinidine?

P
Population
Patients with poor renal function (n=8), congestive heart failure (n=8), and controls (n=9) for half-life determination; patients treated for arrhythmias (n=14) and congestive heart failure (n=12) for steady-state concentration measurement.
I
Intervention
Quinidine
C
Comparator
Controls (for the half-life determination group)
O
Outcome
Plasma quinidine half-life values and steady-state plasma quinidine concentrationssurrogate

Quinidine elimination appears to be grossly normal in patients with congestive heart failure or poor renal function, indicating that major dose adjustments may not be necessary for these conditions.

Cite This Study

Kessler et al. (1974) studied this question.

synapsesocial.com/papers/6a83080f1557c09efd7d5953https://doi.org/10.1056/nejm197403282901303

Topics

Heart failureHFrEF treatment
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