Why the study?
Does quinidine administration alter the pharmacokinetics of digoxin in cardiac patients on long-term digoxin treatment?
Population
11 cardiac patients on long-term digoxin treatment
Comparison
Quinidine administration vs Baseline
Design
Cohort
Authors
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May warrant digoxin level monitoring with quinidine co-use; leaves open need for randomized confirmation of dosing guidance.
Does quinidine administration alter the pharmacokinetics of digoxin in cardiac patients on long-term digoxin treatment?
Quinidine significantly alters digoxin kinetics by decreasing its renal clearance and increasing plasma concentrations, highlighting a clinically important drug-drug interaction.
Pedersen et al. (1980) studied this question.
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