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February 1, 1981British Journal of Clinical PharmacologyOpen Access

Pharmacokinetics of digoxin in patients subjected to the quinidine‐ digoxin interaction.

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Why the study?

Does quinidine alter the pharmacokinetics of digoxin in patients with atrial fibrillation?

Population

5 patients with atrial fibrillation on maintenance digoxin therapy

Comparison

Quinidine therapy vs Baseline (before quinidine therapy)

Design

Case_series

Authors

KSKarin Schenck‐GustafssonCross-Cutting CardiologyRDR. DahlqvistUmeå University

Discussion

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Implication

May raise digoxin levels in AF via reduced clearance; leaves open confirmation in controlled studies.

Structured PICO

Does quinidine alter the pharmacokinetics of digoxin in patients with atrial fibrillation?

P
Population
5 patients with atrial fibrillation on maintenance digoxin therapy
I
Intervention
Quinidine therapy (with [3H]-digoxin given as a single i.v. dose to assess pharmacokinetics)
C
Comparator
Baseline (before quinidine therapy)
O
Outcome
Pharmacokinetics of digoxin (steady state plasma concentration, volume of distribution, renal clearance, total body clearance, elimination half-life)surrogate

Quinidine significantly alters digoxin pharmacokinetics by decreasing its volume of distribution and renal clearance, leading to increased plasma concentrations.

Cite This Study

Schenck‐Gustafsson et al. (1981) studied this question.

synapsesocial.com/papers/6a9587df19dbadbb777cfc45https://doi.org/10.1111/j.1365-2125.1981.tb01122.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Digoxin-Quinidine Interaction1979 · 291 citations
  2. 2Effect of quinidine on plasma concentration and renal clearance of digoxin. A clinically important drug interaction.1980 · 53 citations
  3. 3Effect of quinidine on plasma concentrations of digoxin.1978 · 154 citations
  4. 4Quinidine dosage, with special reference to an oral loading dose schedule.1979 · 6 citations
  5. 5Renal Tubular Secretion of Digoxin1974 · 185 citations