Key result
Quinidine therapy significantly decreased renal clearance of digoxin from 1.19 to 0.86 ml/min/kg (P<0.02) and extrarenal clearance from 0.85 to 0.49 ml/min/kg (P<0.02).
Why the study?
Does quinidine therapy alter steady-state digoxin pharmacokinetics in cardiac patients on long-term digoxin?
Population
7 cardiac patients on long-term digoxin therapy
Comparison
Quinidine therapy vs Absence of quinidine (baseline)
Design
Cohort
Authors
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Quinidine may reduce digoxin clearance in cardiac patients; this Level 3 cohort finding leaves open the need for prospective confirmation before guiding therapy.
Does quinidine therapy alter steady-state digoxin pharmacokinetics in cardiac patients on long-term digoxin?
Absolute Event Rate: 0.86% vs 1.19%
p-value: p=<0.02
Quinidine significantly alters digoxin pharmacokinetics by decreasing both renal and extrarenal clearance and increasing half-life, highlighting a critical drug-drug interaction.
Pedersen et al. (1983) studied Cardiac patients on long-term digoxin therapy (n=7). Quinidine vs. Absence of quinidine was evaluated on Renal clearance of digoxin (ml/min/kg) (p=<0.02). Quinidine therapy significantly decreased renal clearance of digoxin from 1.19 to 0.86 ml/min/kg (P<0.02) and extrarenal clearance from 0.85 to 0.49 ml/min/kg (P<0.02).
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