Why the study?
Does quinidine therapy increase serum digoxin concentration in adults on stabilized digoxin therapy?
Population
15 adults with stabilized serum digoxin concentrations
Comparison
Quinidine therapy vs Baseline (before quinidine therapy)
Design
Cohort
Follow-up
4 days
Authors
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Quinidine coadministration was associated with higher digoxin levels; leaves open whether monitoring improves outcomes in prospective trials.
Does quinidine therapy increase serum digoxin concentration in adults on stabilized digoxin therapy?
Quinidine therapy significantly increases serum digoxin concentrations by decreasing its renal clearance, necessitating close monitoring during the first 4 days of co-administration.
Dennis Mungall (1980) studied this question.
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