Why the study?
Does quinidine administration increase the cardiac effect of digoxin in patients on stable digoxin therapy?
Population
3 patients with stable clinical condition and stable serum digoxin concentration
Comparison
Quinidine administration vs Baseline and after quinidine discontinuation
Design
Case_series
Authors
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May warrant caution with quinidine in digoxin-treated patients; leaves open confirmation in prospective studies.
Does quinidine administration increase the cardiac effect of digoxin in patients on stable digoxin therapy?
The addition of quinidine to stable digoxin therapy increases serum digoxin levels and enhances its cardiac effects, highlighting a significant drug-drug interaction.
Edward B. Leahey (1979) studied this question.
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