Key result
Concomitant treatment with quinidine for 1 week abolished the positive inotropic effect of digoxin in healthy subjects.
Why the study?
Does concomitant quinidine administration alter the positive inotropic effect of digoxin in healthy subjects?
Population
6 healthy subjects
Comparison
Digoxin with concomitant quinidine for 1 week vs Digoxin alone
Design
Other
Follow-up
1 week
Authors
Loading...
May blunt digoxin's inotropic effects with quinidine; hypothesis-generating and requires validation in heart failure patients before any practice change.
Does concomitant quinidine administration alter the positive inotropic effect of digoxin in healthy subjects?
Concomitant administration of quinidine abolishes the positive inotropic effect of digoxin, suggesting their combination should be reconsidered.
Steiness et al. (1980) studied Healthy subjects (n=6). Quinidine vs. Digoxin alone (baseline) was evaluated on Myocardial performance evaluated by systolic time intervals (positive inotropic effect). Concomitant treatment with quinidine for 1 week abolished the positive inotropic effect of digoxin in healthy subjects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: