Why the study?
Does the addition of quinidine to digoxin therapy increase serum digoxin concentrations?
Population
79 patients and 5 volunteers, including 38 patients on a constant glycoside maintenance dose
Comparison
Addition of quinidine to digoxin therapy vs Digoxin therapy alone
Design
Cohort
Authors
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Quinidine co-administration was associated with higher digoxin exposure; supports monitoring but should not yet change practice without RCTs.
Does the addition of quinidine to digoxin therapy increase serum digoxin concentrations?
Co-administration of quinidine and digoxin significantly increases serum digoxin levels by reducing renal clearance, necessitating a 30-50% reduction in digoxin dose to prevent toxicity.
W. Doering (1979) studied this question.
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