Why the study?
Does the addition of quinidine to digoxin therapy increase serum digoxin concentrations?
Population
79 patients and 5 volunteers, including a subgroup of 38 patients on a constant glycoside maintenance dose.
Comparison
Addition of quinidine to digoxin therapy vs Baseline
Design
Cohort
Authors
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Alerts clinicians to digoxin-quinidine interaction risk; leaves open confirmation of dose adjustments in randomized trials.
Does the addition of quinidine to digoxin therapy increase serum digoxin concentrations?
Co-administration of quinidine and digoxin significantly increases serum digoxin levels by reducing renal clearance, necessitating a 30 to 50 percent reduction in digoxin dose to prevent toxicity.
Powell et al. (1980) studied this question.
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