Key result
Addition of quinidine to patients on maintenance digoxin therapy caused an unpredictably large increase in plasma digoxin levels (between 20 and 330% after 3 days) and decreased renal clearance.
Why the study?
Does the addition of quinidine increase plasma digoxin levels in patients on maintenance digoxin therapy?
Population
30 patients on maintenance digoxin therapy admitted for cardioversion of atrial fibrillation
Design
Cohort
Follow-up
3 days
Authors
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May warrant digoxin monitoring with quinidine coadministration; leaves open need for randomized confirmation before routine dose changes.
Observational (n=30)
Does the addition of quinidine increase plasma digoxin levels in patients on maintenance digoxin therapy?
Quinidine causes a clinically important and unpredictably large increase in plasma digoxin levels, necessitating close monitoring and appropriate dose reduction.
Dahlqvist et al. (1980) conducted an observational in Atrial fibrillation (n=30). Quinidine vs. Baseline (digoxin alone) was evaluated on Plasma levels of digoxin. Addition of quinidine to patients on maintenance digoxin therapy caused an unpredictably large increase in plasma digoxin levels (between 20 and 330% after 3 days) and decreased renal clearance.
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