Why the study?
Does quinidine alter the pharmacokinetics of digoxin in subjects?
Population
6 subjects
Comparison
Quinidine administered along with digoxin vs Digoxin alone
Design
Other
Authors
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Supports closer digoxin monitoring with quinidine co-use; leaves open optimal dose adjustments in broader populations.
Does quinidine alter the pharmacokinetics of digoxin in subjects?
Quinidine significantly alters digoxin pharmacokinetics by reducing its clearance and volume of distribution, explaining the clinically observed increase in digoxin plasma concentrations.
Hager et al. (1979) studied this question.
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