Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients

Figures

• 

  FIGURE 1. Platelet factor 4 (PF4) levels in the von Willebrand disease (VWD) cohort. Distribution of PF4 plasma levels in ng/ml are shown per subtype of VWD. Subtypes are type 1 (n = 368), type 2A (n = 125), type 2B (n = 50), type 2M (n = 20), type 2N (n = 12) and type 3 (n = 19). Data shown as median ± interquartile range. ****, p < 0.0001 [Colour figure can be viewed at wileyonlinelibrary.com]

• 

  FIGURE 2. Platelet factor 4 (PF4) levels in relation to current bleeding phenotype in the von Willebrand disease (VWD) cohort. PF4 plasma levels were related to bleeding that required treatment in the year prior to inclusion. For this analysis, PF4 was subdivided into quartiles: 0.00–65.00 ng/ml (Q1), 65.40–105.90 ng/ml (Q2), 106.30–161.00 ng/ml (Q3) and 161.80–384.50 ng/ml (Q4). The proportion of patients with no bleeding (no bleed, blue) versus bleeding (bleed, red) were plotted across the four quartiles of PF4 levels (A). Bleeding versus PF4 levels are also plotted per subtype and total population (B). Data are shown as proportion (A) and median ± interquartile range (B) [Colour figure can be viewed at wileyonlinelibrary.com]