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March 1, 1985British Journal of Haematology

Differentiation of patients with subtype IIb‐like von Willebrand's disease by means of perfusion experiments with reconstituted blood

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Population

12 patients total: 4 unrelated patients with subtype IIb-like von Willebrand's disease, 4 patients with VWD…

Comparison

Perfusion experiments with reconstituted blood vs Normal platelets and normal plasma

Design

Case_series

Authors

KSKjell S. SakaríassenRoche (Switzerland)HNH. Karel NieuwenhuisUniversity Medical Center UtrechtJSJan J. SixmaLeiden University

Discussion

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Implication

Indicates heterogeneity in IIb-like VWD; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
12 patients total: 4 unrelated patients with subtype IIb-like von Willebrand's disease (bleeding diathesis, thrombocytopenia, large platelets, decreased FVIII-VWF), 4 patients with VWD subtype I, and 4 patients with VWD subtype IIa.
I
Intervention
Perfusion experiments with reconstituted blood (patient platelets in normal plasma or normal platelets in patient plasma)
C
Comparator
Normal platelets and normal plasma
O
Outcome
Platelet adherence to human artery subendotheliumsurrogate

Perfusion experiments with reconstituted blood can differentiate between intrinsic platelet abnormalities and plasma defects in patients with subtype IIb-like von Willebrand's disease, revealing heterogeneity that may impact treatment.

Cite This Study

Sakaríassen et al. (1985) studied this question.

synapsesocial.com/papers/6a7381e1d3d4e530dbfb684chttps://doi.org/10.1111/j.1365-2141.1985.tb07333.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heightened Interaction between Platelets and Factor VIII/von Willebrand Factor in a New Subtype of von Willebrand's Disease1980 · 374 citations
  2. 2Platelet-type von Willebrand's disease: characterization of a new bleeding disorder1982 · 202 citations
  3. 3Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets1982 · 21 citations
  4. 4Adhesion of platelets to human artery subendothelium: effect of factor VIII-von Willebrand factor of various multimeric composition1984 · 134 citations
  5. 5DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium1984 · 157 citations