July 1, 1986American Journal of Hematology
Investigation of a case of subtype IIC von Willebrand disease: Characterization of the variability of this subtype
Population
19-year-old woman with a severe bleeding syndrome and her family members (5 from the maternal side)
Design
Case_report
Authors
Discussion
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Member takes
Implication
Alerts clinicians to possible DDAVP nonresponse in type IIC vWD variants; leaves open broader phenotypic classification requiring further study.
Structured PICO
P
Population
19-year-old woman with a severe bleeding syndrome and her family members (5 from the maternal side)
I
Intervention
Characterization of von Willebrand factor (vWF) using crossed immunoelectrophoresis (CIE), SDS-agarose electrophoresis, and DDAVP administration
O
Outcome
Characterization of vWF multimeric structure and phenotypic variabilitysurrogate
This case report identifies phenotypic variability in subtype IIC von Willebrand disease, notably a low level of platelet vWF:Ag and a lack of vWF increase following DDAVP administration.
Cite This Study
Mazurier et al. (1986) studied this question.