Key result
Hypoxia, halothane, arterial occlusion, and hemorrhage lower the pressure threshold for circulatory deficits in rabbits.
Arterial hypoxia, halothane anesthesia, local arterial occlusion, and acute hemorrhage reduce tissue pressure tolerance, suggesting higher risk for tissue damage in patients with peripheral vascular disease or hemorrhage.
May warrant caution in compromised patients; leaves open translation of rabbit thresholds to human pressure injury risk.
The tolerance of neuromuscular tissue for increased tissue pressure has been observed clinically to vary among individuals. In experimental operations on rabbits, various factors may affect tissue pressure tolerance. Arterial hypoxia, halothane anesthesia, local arterial occlusion, and acute hemorrhage each reduced the amount of pressure necessary to produce circulatory and functional deficits. Extrapolation of these observations suggest that patients with hemorrhage, arterial hypoxia, and peripheral vascular disease may be at greater risk from a given tissue pressure than patients without these conditions.
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Matsen et al. (1981) studied Increased tissue pressure. Arterial hypoxia, halothane anesthesia, local arterial occlusion, and acute hemorrhage was evaluated on Amount of pressure necessary to produce circulatory and functional deficits. Arterial hypoxia, halothane anesthesia, local arterial occlusion, and acute hemorrhage each reduced the amount of pressure necessary to produce circulatory and functional deficits in rabbits.
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