Key result
Increasing compartment pressure reduces perfused capillaries, halting flow completely within ~26 mm Hg of MAP.
Why the study?
Does increased compartment pressure reduce capillary perfusion in skeletal muscle in a rat model?
Does increased compartment pressure reduce capillary perfusion in skeletal muscle in a rat model?
p-value: p=< 0.05
Increasing compartment pressure reduces the number of perfused capillaries, with complete cessation of flow when compartment pressure is within about 25 mm Hg of mean arterial pressure.
No takes yet. Share an insight, caveat, or question.
Compartment pressures near MAP may abolish muscle capillary flow; leaves open translation to human compartment syndrome thresholds.
Hartsock et al. (1998) studied Elevated tissue pressure (n=10). Increased compartment pressure vs. 0 mm Hg was evaluated on Number of capillaries per 10,000 square micrometers with blood flowing (p=< 0.05). Increasing compartment pressure significantly reduced the number of perfused capillaries (P<0.05), with complete cessation of flow when pressure was within 25.5 mm Hg of mean arterial pressure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: