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Hypertrophic cardiomyopathy is a genetic cardiac disorder affecting approximately 2 in 1000 young adults and is the most frequent cause of sudden cardiac death in young athletes.
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Hypertrophic cardiomyopathy is a common genetic disorder and a frequent cause of sudden cardiac death in young athletes, driven by sarcomere protein mutations.
Hypertrophic cardiomyopathy (HCM) is a common genetic cardiac disorder that causes distinctive anatomic and histologic features as well as a wide array of clinical manifestations [1]. HCM is the most frequent cause of sudden cardiac death in young athletes [2]. Morphologic features of HCM include ventricular hypertrophy that is usually asymmetric and particularly involves the interventricular septum. Epidemiologic data indicate that 2 in 1000 young adults have unexplained hypertrophy [2]. Mutations in genes that encode sarcomere proteins including cardiac myosin binding protein C gene (MYBPC3), cardiac troponin T gene (TNNT2), cardiac troponin I gene (TNNI3), and cardiac beta-myosin heavy chain gene (MYH7) are well-established causes of the disease [1,3].
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Fujino et al. (2014) conducted a review in Hypertrophic cardiomyopathy (HCM). Hypertrophic cardiomyopathy is a genetic cardiac disorder affecting approximately 2 in 1000 young adults and is the most frequent cause of sudden cardiac death in young athletes.
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