Key result
Severe dynamic hyperinflation lowers heart rate-adjusted transmitral E/A-ratio by ~12% versus tachypnea alone.
Why the study?
Dynamic hyperinflation has been suggested as a key determinant of reduced left ventricular diastolic function in COPD, but other confounding disease mechanisms needed to be excluded.
Does induced dynamic hyperinflation reduce left ventricular diastolic function in healthy subjects?
Population
14 healthy male subjects
Comparison
Expiratory resistance breathing to induce dynamic hyperinflation vs tachypnea alone
Design
Randomized controlled crossover trial
Authors
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Induced dynamic hyperinflation impairs LV diastolic function in healthy subjects; extends causal evidence for hyperinflation reduction as a treatable trait in COPD.
RCT (n=14)
Investigator-blinded
Blocks of four
No
Does induced dynamic hyperinflation reduce left ventricular diastolic function in healthy subjects?
Absolute Event Rate: 1.63% vs 1.85%
p-value: p=0.039
Induced dynamic hyperinflation acutely impairs left ventricular diastolic function in healthy subjects, suggesting hyperinflation is a direct mechanical cause of diastolic dysfunction in COPD.
Urban et al. (2021) conducted an RCT in Healthy subjects (n=14). Expiratory resistance breathing (ERB) vs. Tachypnea alone was evaluated on Heart rate-adjusted transmitral E/A-ratio (p=0.039). Severe dynamic hyperinflation induced by expiratory resistance breathing significantly decreased the heart rate-adjusted transmitral E/A-ratio compared to tachypnea alone (1.63 vs 1.85, p=0.039) in healthy male subjects.
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