Key result
Pacemaker implantation is linked to an ~8% LVEF drop and increased coagulation at 7 days.
Why the study?
Does permanent cardiac pacemaker implantation affect vascular endothelial function, blood coagulation, and cardiac function in patients with bradycardia?
Population
117 patients with bradycardia and 53 healthy controls. Total n=170.
Comparison
Permanent cardiac pacemaker implantation vs Healthy controls and non-pacemaker bradycardia…
Design
Cohort
Follow-up
7 days after implantation
Authors
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Pacemaker implantation may alter endothelial/coagulation markers in bradycardia; leaves open clinical relevance pending outcome trials.
Observational (n=170)
No
Does permanent cardiac pacemaker implantation affect vascular endothelial function, blood coagulation, and cardiac function in patients with bradycardia?
Absolute Event Rate: 53.23% vs 61.59%
p-value: p=<0.05
Permanent pacemaker implantation in bradycardia patients is associated with worsened vascular endothelial function, hypercoagulability, and reduced cardiac function, though DDD pacemakers mitigate some of these adverse effects compared to VVI pacemakers.
Zhang et al. (2018) conducted an observational in Bradycardia (n=170). Permanent cardiac pacemaker implantation vs. Before implantation was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.05). Permanent cardiac pacemaker implantation in patients with bradycardia significantly reduced left ventricular ejection fraction from 61.59% to 53.23% at 7 days post-implantation, while increasing markers of blood coagulation and endothelial damage.
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