Key result
Using perfusion area and collateral flow as independent variables explained 80% of the variance in infarct size, allowing accurate prediction of infarct size in a dog model of regional ischemia.
Incorporating both perfusion area and collateral flow allows for accurate prediction of infarct size in a dog model, providing an efficient method to evaluate cardioprotective drugs.
May streamline cardioprotective drug testing in canine ischemia models; leaves open translation to clinical practice.
The variables related to infarct size were examined in order to develop an efficient procedure for the assessment of cardioprotective action in the dog. In the open chest model the left anterior descending coronary artery was ligated for 90 or 240 min. Regional myocardial blood flow was measured by tracer microspheres and infarct size was studied using triphenyltetrazoliumchloride. Infarct size was measured in relation to perfusion area, collateral flow, and rate pressure product. Using perfusion area as an independent variable, only 61% of the variance in infarct size could be explained. Including collateral flow also, this percentage increased to 80. Using perfusion area and collateral flow, infarct size could be predicted accurately. The usefulness of this procedure is demonstrated by data obtained with test compound R 51 430.
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Vandeplassche et al. (1986) studied Regional ischemia of the heart. Test compound R 51 430 was evaluated on Infarct size variance explained by perfusion area and collateral flow. Using perfusion area and collateral flow as independent variables explained 80% of the variance in infarct size, allowing accurate prediction of infarct size in a dog model of regional ischemia.
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