Key result
Verapamil treatment in rats reduced infarct size by 20% at 5 hours and 12% at 24 hours after coronary occlusion, but was associated with large postoperative mortality.
Why the study?
Does verapamil reduce infarct size in a rat model of myocardial infarction?
Population
Rat model of myocardial infarction induced by left coronary artery occlusion
Comparison
Verapamil treatment vs Untreated rats
Design
Preclinical
Follow-up
5 hours and 24 hours
Authors
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Verapamil-associated mortality in rat MI models cautions against translation; leaves open whether refined dosing extends infarct-size benefits.
Does verapamil reduce infarct size in a rat model of myocardial infarction?
Effect estimate: 20% reduction at 5 h, 12% reduction at 24 h
TTC staining provides reliable demarcation of infarct size in rats, and while verapamil reduces infarct size in this model, high mortality and nonuniform infarcts complicate translation to clinical trials.
Greve et al. (1991) studied Myocardial infarction. Verapamil vs. Untreated rats was evaluated on Infarct size (20% reduction at 5 h, 12% reduction at 24 h). Verapamil treatment in rats reduced infarct size by 20% at 5 hours and 12% at 24 hours after coronary occlusion, but was associated with large postoperative mortality.
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