Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 11, 2016Journal of Visualized Experiments

Histological Quantification of Chronic Myocardial Infarct in Rats

View Full Paper
Ask AI
Bookmark
Share

Population

Rat model of chronic myocardial infarction induced by permanent coronary ligation

Design

Preclinical

Authors

JVJérémy ValentinUniversity Hospital of BernAFAurélien FrobertUniversity of FribourgGAGuillaume AjalbertUniversity of Fribourg

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for chronic post-MI remodeling visualization in rodents; leaves open translational utility pending validation.

Structured PICO

P
Population
Rat model of chronic myocardial infarction induced by permanent coronary ligation
I
Intervention
Systematic sampling of harvested rat heart and image analyses of trichromatic stained histological sections from base to apex, with calculation of the expansion index (EI)
O
Outcome
Infarct size assessment accounting for left ventricle remodelingsurrogate

Standardized systematic sampling and expansion index calculation provides a more accurate histological assessment of infarct size in rat models of chronic MI.

Cite This Study

Valentin et al. (2016) studied this question.

synapsesocial.com/papers/6a90d4418b76b10fb073c787https://doi.org/10.3791/54914
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic myocardial infarction in the mouse: cardiac structural and functional change1999 · 182 citations
  2. 2Effect of Injectable Alginate Implant on Cardiac Remodeling and Function After Recent and Old Infarcts in Rat2008 · 451 citations
  3. 3Steroid administration after myocardial infarction promotes early infarct expansion. A study in the rat.1987 · 62 citations
  4. 4Optimized Heart Sampling and Systematic Evaluation of Cardiac Therapies in Mouse Models of Ischemic Injury: Assessment of Cardiac Remodeling and Semi‐Automated Quantification of Myocardial Infarct Size2015 · 5 citations
  5. 5Prognostic Value of Troponin I for Infarct Size to Improve Preclinical Myocardial Infarction Small Animal Models2015 · 30 citations