Key result
The rat model of acute myocardial infarction, induced by 30-minute LAD ligation and reperfusion, is a useful method for studying cardiac pathophysiological function and remodeling.
Population
Rat model of acute myocardial infarction (AMI) / ischemia-reperfusion (IR)
Design
Preclinical
Follow-up
4 hours of reperfusion
Authors
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Provides standardized rat MI model for mechanistic studies; leaves open clinical translation pending human validation.
This report provides a detailed methodology for the rat model of acute myocardial infarction and ischemia-reperfusion to study cardiovascular disease mechanisms and treatments.
Wu et al. (2011) studied Acute Myocardial Infarction. Acute myocardial infarction model (LAD ligation) was evaluated on Infarct size and area-at-risk (AAR). The rat model of acute myocardial infarction, induced by 30-minute LAD ligation and reperfusion, is a useful method for studying cardiac pathophysiological function and remodeling.
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