Key result
Rat models remain relevant for understanding the underlying mechanisms and testing antiarrhythmic therapies for ventricular arrhythmias occurring during the acute phase of myocardial infarction.
Rat models provide a valuable preclinical platform for investigating the mechanisms and potential treatments of acute ischemia-induced ventricular fibrillation.
Does not change acute MI arrhythmia management; extends support for rat models in preclinical mechanism and therapy studies.
A number of animal models have been designed in order to unravel the underlying mechanisms of acute ischemia-induced arrhythmias and to test compounds and interventions for antiarrhythmic therapy. This is important as acute myocardial infarction (AMI) continues to be the major cause of sudden cardiac death, and we are yet to discover safe and effective treatments of the lethal arrhythmias occurring in the acute setting. Animal models therefore continue to be relevant for our understanding and treatment of acute ischemic arrhythmias. This review discusses the applicability of the rat as a model for ventricular arrhythmias occurring during the acute phase of AMI. It provides a description of models developed, advantages and disadvantages of rats, as well as an overview of the most important interventions investigated and the relevance for human pathophysiology.
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Hundahl et al. (2017) conducted a review in Ventricular fibrillation following acute myocardial infarction. Rat models was evaluated. Rat models remain relevant for understanding the underlying mechanisms and testing antiarrhythmic therapies for ventricular arrhythmias occurring during the acute phase of myocardial infarction.
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