Why the study?
Existing rat models of post-MI heart failure have high mortality, large variations in infarct size and cardiac function, and require ventilators or heart exteriorization.
Population
Rats
Comparison
LAD coronary artery ligation without ventilator or heart exteriorization vs sham
Design
Preclinical animal model study
Follow-up
Four weeks
Authors
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Improved rat post-MI HF model may reduce mortality and variability; leaves open translation beyond rodents.
A simplified LAD ligation technique without mechanical ventilation or heart exteriorization creates a reliable and reproducible rat model of post-MI heart failure.
Li et al. (2021) studied this question.
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