Population
Lewis inbred rats and Sprague-Dawley rats
Comparison
Ligation of the left anterior descending… vs Sprague-Dawley rats and sham operation
Design
Preclinical
Follow-up
6 months
Authors
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Supports Lewis rats for consistent chronic post-MI HF modeling; leaves open translation to clinical research.
Coronary ligation in Lewis inbred rats provides a reliable preclinical model of chronic heart failure with uniformly large infarcts, low mortality, and progressive left ventricular dysfunction.
Liu et al. (1997) studied this question.
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