Key result
LAD ligation plus sugen induces combined LV dysfunction and precapillary PAH with RVSP ~78 mmHg.
No takes yet. Share an insight, caveat, or question.
Combined LAD ligation and sugen injection successfully establishes a novel rat model of biventricular heart failure with precapillary pulmonary arterial hypertension.
Miklovič et al. (2025) studied Myocardial infarction and pulmonary arterial hypertension. LAD ligation combined with sugen injection vs. Sham/placebo or IM/placebo was evaluated on Development of LV dysfunction and precapillary PAH (RV systolic pressure, EF). Combined LAD ligation and sugen injection in rats successfully induced a double-hit model of LV dysfunction and precapillary pulmonary arterial hypertension, with RV systolic pressures reaching 78 ± 10 mmHg (p<0.001 vs sham).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: