Key result
Permanent left coronary artery ligation provides a reliable, less invasive murine model for post-MI studies.
Why the study?
Research models of myocardial infarction are needed to explore post-MI pathophysiological changes and design future treatments.
Population
Mice
Comparison
Permanent ligation of the left coronary artery
Design
Surgical murine model protocol
Follow-up
Day 28
Authors
Loading...
May enable standardized post-MI mechanistic studies in mice; leaves open clinical translation.
This paper provides a detailed methodology for a reproducible surgical murine model of myocardial infarction to study post-MI pathophysiology and heart failure.
Johny et al. (2022) studied Myocardial infarction. Left coronary artery ligation was evaluated on Cardiac function and ventricular remodeling post MI. Permanent ligation of the left coronary artery provides a less invasive, reliable, and reproducible surgical murine model for studying pathophysiological and immunological alterations after MI.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: