Key result
An improved murine model for myocardial infarction via permanent LAD ligation reduces surgical complications and mortality by utilizing reversible anesthesia, minimally invasive intubation, and thoracentesis.
Population
Murine model
Design
Preclinical
Authors
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Provides standardized permanent LAD ligation protocol for mouse MI models; extends technical resources but leaves open cross-lab validation.
An improved, less invasive murine model for myocardial infarction via LAD ligation reduces surgical mortality and improves reproducibility for preclinical research.
Reichert et al. (2017) studied Ischemic heart disease / Myocardial infarction. Murine Left Anterior Descending (LAD) Coronary Artery Ligation vs. Other surgical methods was evaluated. An improved murine model for myocardial infarction via permanent LAD ligation reduces surgical complications and mortality by utilizing reversible anesthesia, minimally invasive intubation, and thoracentesis.
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