Key result
Ligation of the proximal segment of the left coronary artery in mice typically induces an infarct size of approximately 40% of the left ventricle.
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Establishes reproducible proximal coronary ligation for mouse MI modeling; leaves open translation to human therapeutics.
Shao et al. (2013) studied Myocardial infarction. Coronary artery ligation was evaluated on Infarct size. Ligation of the proximal segment of the left coronary artery in mice typically induces an infarct size of approximately 40% of the left ventricle.
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