Key result
A surgical protocol for permanent ligation of the left anterior descending coronary artery in mice was described to generate a highly reproducible model of myocardial infarction.
Why the study?
Myocardial infarction is a leading cause of death worldwide, and animal models mimicking human acute coronary syndrome are needed to study pathophysiology and develop therapies.
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Provides standardized mouse MI ligation protocol with videos; extends reproducible preclinical modeling for ACS research.
Maruyama et al. (2021) studied Myocardial infarction. Permanent ligation of the left anterior descending coronary artery was evaluated. A surgical protocol for permanent ligation of the left anterior descending coronary artery in mice was described to generate a highly reproducible model of myocardial infarction.
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