Forskolin (1)(7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one), the major diterpenoid of Coleus forskohlii, has potent positive inotropic, antihypertensive, and adenylate cyclase stimulant properties. The reactivity of its various functional groups (1α-OH, 6β-OH, the derived 7β;-OH, 9α-OH, 11-oxo, and 14,15-double bond) has been studied through acylation, alkylation, dehydration, oxidation, and reduction reactions.
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Bhat et al. (1982) studied this question.
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