Key result
Lycium barbarum polysaccharides reduce doxorubicin-induced testicular toxicity in rats by attenuating oxidative stress.
Why the study?
Does Lycium barbarum polysaccharides protect against doxorubicin-induced testicular toxicity in male Sprague-Dawley rats?
Does Lycium barbarum polysaccharides protect against doxorubicin-induced testicular toxicity in male Sprague-Dawley rats?
Lycium barbarum polysaccharides may protect against doxorubicin-induced testicular oxidative stress and toxicity in a rat model.
Hypothesis-generating in rats; leaves open whether Lycium barbarum polysaccharides mitigate doxorubicin testicular toxicity clinically.
The present study aimed to investigate whether Lycium barbarum polysaccharides (LBP) would protect against doxorubicin (DOX)-induced testicular toxicity. Male Sprague-Dawley rats were treated with distilled water (4 mL/kg) or LBP (200 mg/kg, p.o.) daily for 10 days and followed by saline (0.9 %, 10 mL/kg) or DOX (10 mg/kg) intravenous injection at day 7. Pretreatment with LBP ameliorated DOX-induced reduction in the testicular weights, sperm concentrations and percentage of motile sperms, as well as the increase in abnormal sperm rate. LBP administration to DOX-treated rats successfully reversed the changes in MDA and GHS-Px levels. Compared with the control, pretreatment with LBP significantly increased the plasma testosterone level in the LBP + DOX group. The histopathology examinations further confirmed that LBP effectively attenuated DOX-induced severe degenerative changes of seminiferous tubules. This study illustrated the capability of LBP in attenuating testicular oxidative stress and protecting testis-specific toxicity in DOX-exposed rats.
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Xin et al. (2011) studied Doxorubicin-induced testicular toxicity. Lycium barbarum polysaccharides (LBP) vs. Distilled water (4 mL/kg) was evaluated on Testicular toxicity (testicular weights, sperm parameters, oxidative stress markers, and histopathology). Pretreatment with Lycium barbarum polysaccharides ameliorated doxorubicin-induced testicular toxicity in rats, improving sperm parameters and attenuating oxidative stress and degenerative changes.
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