July 11, 2007Phytotherapy Research

Protective effect of Lycium barbarum on doxorubicin‐induced cardiotoxicity

View Full Paper

Ask AI

Bookmark

Why the study?

Does Lycium barbarum prevent doxorubicin-induced cardiotoxicity in male SD rats?

Population

Male SD rats

Comparison

Water extract of Lycium barbarum and doxorubicin… vs Distilled water and doxorubicin for 3 weeks

Design

Preclinical

Follow-up

3 weeks

Authors

YXYanfei XinHuygens Institute for History and Culture of the Netherlands GZGuoliang ZhouXi'an Jiaotong University ZDZu‐Yue DengZhejiang University of Technology

Discussion

Member takes

Implication

Should not change clinical practice; extends preclinical evidence for Lycium barbarum in doxorubicin cardiotoxicity.

Structured PICO

Does Lycium barbarum prevent doxorubicin-induced cardiotoxicity in male SD rats?

Population

Male SD rats

Intervention

Water extract of Lycium barbarum (25 mg/kg, p.o. daily) and doxorubicin (5 mg/kg, i.v. weekly) for 3 weeks

Comparator

Distilled water (p.o. daily) and doxorubicin (5 mg/kg, i.v. weekly) for 3 weeks

Outcome

Mortality, general condition, body weight, electrocardiograph changes, heart antioxidant activity, serum levels of creatine kinase (CK) and aspartate aminotransferase (AST), and histopathological changesurrogate

Lycium barbarum extract demonstrates cardioprotective effects against doxorubicin-induced cardiotoxicity in a rat model without compromising the in vitro antitumor activity of doxorubicin.

Cite This Study

Xin et al. (2007) studied this question.

synapsesocial.com/papers/6a815632d7cc3676436625ae https://doi.org/10.1002/ptr.2186

View Full Paper

Ask AI

Bookmark

Protective effect of Lycium barbarum on doxorubicin‐induced cardiotoxicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protective effect of Lycium barbarum on doxorubicin‐induced cardiotoxicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider