Prophylactic impacts of Lagenaria siceraria against cardiomyopathy induced by doxorubicin in a rat model

Figures

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  Fig. 1.. (A-D) Impacts of doxorubicin (DOX) (10 mg/kg.bw.), LSSO (3 g/kg.b w) and their combination on the serum aspartate aminotransferase (AST) activity (Fig. 1A), LDH (Fig. 1B), creatine kinase-MB isoenzyme (CK-MB, Fig. 1C) and Troponine I (Fig. 1D) of rats. The CON group, where rats received normal saline orally (1 ml/kg b.w). a, b,c, and d mean in the same row with different superscripts are significantly (p < 0.05) different.

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  Fig. 2.. (A-C) Impacts of doxorubicin (DOX) (10 mg/kg.bw.), LSSO (3 g/kg.b.w), and their combination on the rats heart tissues of reduced GSH (Fig. 2A), catalase (Fig. 2B), and MDA (Fig. 2C). The CON group, where rats were received normal saline orally (1 ml/kg bw). a, b,c, and d mean in the same row with different superscripts are significantly (p < 0.05) different.

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  Fig. 3.. (A, B) Histological photograph (H & E) of heart tissue of rats CTR who received normal saline orally (1 ml/kg b w) for 18 days. Heart tissues of rats under magnification of 10X (A) and 40X (B). Histological analysis shows normal cardiomyocytes intermuscular and coronary blood vessels.

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  Fig. 4.. (A, B) Histological photograph (H & E) of heart tissue of rats (Doxorubicin group) received DOX (10 mg/kg b.w) for 18 days. Heart tissues (A) show severe congestion of coronary and intermuscular blood vessels (stars, X10). (B). A moderate number of cardiac muscle fibers show hyaline degeneration and dissociation (star, X40).

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  Fig. 5.. (A, B) Histological photograph (H & E) of heart tissue of rats (DOLS) received DOX (10 mg/kg b.w) + 3 g of LSSO/kg of b.w for 18 days. Heart tissues (A) show valvular stagnation of the blood and dissection of the coronary and intermuscular blood vessels were moderately congested (stars, X10). (B). Some of the cardiac muscle fibers (30%–35%) showed hyaline degeneration, swelling and perinuclear vacuolation (star, X40).

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  Fig. 6.. (A-B) Histological photograph (H & E) of heart tissue of rats received 3 g of LSSO/kg of b.w for 18 days. Heart tissues of rats that received LSS showed normal cardiomyocytes, intermuscular (Fig. 6A, X10), and coronary blood vessels with preserved endocardial and valvular endothelium and Purkinje fibers (Fig. 6B, X40).