Key result
Doxorubicin exhibited antioxidant properties by reducing ferrylmyoglobin and inhibiting lipid peroxidation (IC50 ~18 microM), casting doubt on lipid peroxidation as the cause of its cardiotoxicity.
Population
In vitro models including horse heart metmyoglobin and cytosol of human myocardial biopsies
Design
Preclinical
Authors
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Questions lipid peroxidation's role in doxorubicin cardiotoxicity in animals; hypothesis-generating and leaves open human relevance.
p-value: p=0.029
Doxorubicin exhibits antioxidant properties by reducing Mb(IV) to Mb(III) and inhibiting lipid peroxidation, challenging the hypothesis that lipid peroxidation is the primary mechanism of anthracycline-induced cardiotoxicity.
Menna et al. (2002) studied Anthracycline-induced cardiotoxicity. Doxorubicin vs. Other anthracyclines and model compounds was evaluated on Inhibition of Mb(IV)-dependent peroxidation of arachidonic acid (p=0.029). Doxorubicin exhibited antioxidant properties by reducing ferrylmyoglobin and inhibiting lipid peroxidation (IC50 ~18 microM), casting doubt on lipid peroxidation as the cause of its cardiotoxicity.
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