Key result
GALNT13 variant rs10196189 is linked to ~71% greater odds of elite sprint and power performance.
Why the study?
The genetic underpinnings of elite sprint performance remain largely elusive.
Case-Control (n=4,043)
Yes
Identified novel genetic loci, including GALNT13, associated with elite sprint performance across multiple ethnicities.
Requires prospective validation before performance prediction; extends genetic loci for athletic research but leaves clinical utility open.
The genetic underpinnings of elite sprint performance remain largely elusive. For the first time, we uncovered rs10196189 ( GALNT13 ) in the cross-ancestry, genome-wide analysis of elite sprint and power-oriented athletes and their controls from Jamaica, the USA, and Japan, and replicated this finding in two independent cohorts of elite European athletes (meta-analysis P < 5E-08). We identified statistically significant and borderline associations for cross-ancestry and ancestry specific loci in GALNT13 , BOP1 , HSF1 , STXBP2 GRM7 , MPRIP , ZFYVE28, CERS4 , and ADAMTS18 , predominantly expressed in the nervous and hematopoietic systems. Further, we revealed thirty-six previously uncharacterized genes associated with host defence, leukocyte migration, and cellular responses to interferon-gamma and unveiled (reprioritized) four genes, UQCRFS1 , PTPN6 , RALY and ZMYM4, responsible for aging, neurological conditions, and blood disorders from the elite athletic performance cohorts. Our results provide new biological insights into elite sprint performance and offer clues to the potential molecular mechanisms interlinking and operating in elite athletic performance and human health and disease.
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Wang et al. (2023) conducted a case-control in Elite sprint and power-oriented athletic performance (n=4,043). GALNT13 genetic variant rs10196189 vs. Non-carriers / Ancestry-matched controls was evaluated on Elite sprint and power-oriented athletic status (OR 1.71, p=2.28E-09). The GALNT13 genetic variant rs10196189 was significantly associated with elite sprint and power-oriented athletic performance across multiple ancestral cohorts (OR 1.71).
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