Key result
Gene therapy and regenerative medicine offer potential long-term treatment strategies for heart failure by targeting various pathophysiological mechanisms at the cellular and genomic levels.
This review outlines various potential gene therapy strategies for the treatment of heart failure.
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Cautious exploration of gene therapy in heart failure is warranted; leaves open confirmation of long-term benefits in randomized trials.
Every year in the world there is increasing death rates due to heart failure. So it is very essential to cure the heart failure on a long term basis. For this purpose, gene therapy is somehow the best way. We can do this by discovering new pharmacological targets, producing regenerative medicine by use of stem cells, using adipose tissues for cardiac repair, using resynchronization therapy by changing the gene expressions, by correcting the gene expression of connexin43, by enhancing the mitochondrial function, insertion of ACE gene, curing the down regulation of calcium signaling protein, use of micro RNAs, modification of cardiovascular ion channels by gene therapy, silencing the myotrophin gene. Heart failure means the loss of heart functions; heart stops its working which may lead to death. Now a day, heart failure is dominating in the world. There are lots of factors involve in this disease. Journal of College of Medical Sciences-Nepal,2011,Vol-6,No-4, 69-75 DOI: http://dx.doi.org/10.3126/jcmsn.v6i4.6732
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Qadir et al. (2012) conducted a review in Heart failure. Gene therapy was evaluated. Gene therapy and regenerative medicine offer potential long-term treatment strategies for heart failure by targeting various pathophysiological mechanisms at the cellular and genomic levels.
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