Key result
Aging in Down syndrome is linked to slower occipital alpha rhythms versus other intellectual disabilities.
Why the study?
How do EEG patterns change with aging in adults with Down syndrome compared to mentally retarded subjects without DS and healthy volunteers?
Cross-Sectional (n=129)
How do EEG patterns change with aging in adults with Down syndrome compared to mentally retarded subjects without DS and healthy volunteers?
Adults with Down syndrome exhibit age-related slowing of occipital alpha rhythms on EEG that is more pronounced than in mentally retarded controls over 35 years old, though this does not correlate with ADL deterioration.
Answers are grounded in this paper and cite their sources.
Does not support routine EEG monitoring for functional decline in aging Down syndrome; leaves open its value as a biomarker for early dementia.
The EEGs of 40 subjects with Down syndrome (DS) aged 15 to 54 were investigated and compared with those of 42 mentally retarded subjects without DS (MR) and 47 healthy volunteers. The frequencies of the occipital alpha rhythms decreased with age in the DS subjects, and were significantly slower than the MR subjects over 35 years old. The slowing of alpha rhythm in the older DS subjects accompanied an increase of slow activity of 6-8 Hz, but did not relate to the deterioration of activities of daily life (ADL) as estimated by the GBS score. Twenty-one subjects with DS were examined by a CT scan as well, and showed no age-related morphometric changes.
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Yoshiro Ono (1993) conducted a cross-sectional in Down syndrome (n=129). Down syndrome and aging vs. Mentally retarded subjects without DS and healthy volunteers was evaluated on Frequencies of occipital alpha rhythms. Aging in adults with Down syndrome was associated with decreased occipital alpha rhythm frequencies, which were significantly slower than in mentally retarded subjects over 35 years old.
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