Key result
Down Syndrome was associated with a significant inverse correlation between occipital alpha rhythm frequencies and chronological age, unlike healthy or mentally retarded controls.
Cross-Sectional (n=125)
Adults with Down Syndrome show an age-related slowing of occipital alpha rhythm on EEG, suggesting premature aging in the brain.
May reflect atypical brain aging in Down syndrome; leaves open validation as cognitive biomarker.
A power spectral analysis was performed on occipital EEGs recorded from 36 Down Syndrome (DS) subjects aged 15 to 54 and compared with two control groups; 47 healthy volunteers (Control) and 42 mentally retarded people without DS (MR). The frequencies of occipital alpha rhythms of DS showed a significant inverse correlation with chronological age, while Control and MR did not. The average frequencies of DS were significantly low even in the youngest age-group in comparison with those of Control, and also decreased in the age-groups of 35 and older compared with MR. It was considered that a slowing of alpha rhythm was a manifestation of premature aging that occurred in the underdeveloped brains of DS.
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Ono et al. (1992) conducted a cross-sectional in Down Syndrome (n=125). Down Syndrome vs. Healthy volunteers and mentally retarded people without Down Syndrome was evaluated on Frequencies of occipital alpha rhythms and correlation with chronological age. Down Syndrome was associated with a significant inverse correlation between occipital alpha rhythm frequencies and chronological age, unlike healthy or mentally retarded controls.
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