Key result
A porohyperelastic arterial wall model showed maximum LDL concentration at 3% wall thickness from the lumen-wall interface, whereas a rigid model showed it just at the interface.
Population
Computational model of a deformable arterial wall with multiple bends using a porohyperelastic model (PHEM)
Comparison
Fluid-structure interaction coupled analysis of… vs Rigid arterial wall model
Design
Preclinical
Authors
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Porohyperelastic models predict deeper LDL peaks than rigid walls; extends biomechanical simulations but leaves clinical translation open.
Fluid-structure interaction analysis incorporating arterial wall deformation and filtration flow provides a more realistic simulation of LDL accumulation in atherosclerosis than rigid models.
Koshiba et al. (2006) studied Atherosclerosis. Porohyperelastic arterial wall model (PHEM) vs. Rigid model was evaluated on LDL concentration and accumulation. A porohyperelastic arterial wall model showed maximum LDL concentration at 3% wall thickness from the lumen-wall interface, whereas a rigid model showed it just at the interface.
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