Key result
Pregnancies in women with an uncorrected single ventricle were associated with significantly higher rates of perinatal loss (30.0% vs 2.6%, p=0.005) and low birth weight compared to healthy controls.
Why the study?
Women with an uncorrected single ventricle heart face an increased risk of adverse maternal and perinatal outcomes.
What are the maternal and perinatal outcomes of pregnancy in women with uncorrected single ventricles compared to healthy controls?
Case-Control (n=62)
No
What are the maternal and perinatal outcomes of pregnancy in women with uncorrected single ventricles compared to healthy controls?
Absolute Event Rate: 30% vs 2.6%
p-value: p=0.005
Pregnancy in women with uncorrected single ventricles carries a high risk of perinatal loss, low birth weight, and maternal mortality, highlighting the need for prenatal counseling and discouragement of pregnancy in this high-risk group.
BACKGROUND: Women with an uncorrected single ventricle heart are at increased risk of adverse maternal and perinatal outcomes. METHODS: We report our experience of managing pregnant women with uncorrected single ventricles, during the time period 2011 to 2017, in a low-resource setting and compare pregnancy outcome with healthy concurrent controls. Outcomes assessed include the mode of delivery, maternal complications, neonatal death and birth weight. RESULTS: There were six pregnant women with uncorrected single ventricles who had a total of 14 pregnancies. There was one maternal death in a woman with atrioventricular-septal defect and Eisenmenger syndrome. Caesarean section rates and preterm delivery were similar, whereas perinatal loss and low-birth weight rates were higher among women with a single ventricle compared to healthy controls. CONCLUSION: Unplanned pregnancies without prenatal counselling/care pose a challenge to physicians especially in low to middle income countries and with the high risk of morbidity/mortality, pregnancy should be discouraged.
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Keepanasseril et al. (2019) conducted a case-control in Uncorrected single ventricle heart in pregnancy (n=62). Uncorrected single ventricle vs. Healthy pregnant women without heart disease was evaluated on Perinatal loss (p=0.005). Pregnancies in women with an uncorrected single ventricle were associated with significantly higher rates of perinatal loss (30.0% vs 2.6%, p=0.005) and low birth weight compared to healthy controls.
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