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The reduction of cannabidiol (CBD) particle size in suspensions and maintenance of their stability is crucial for improved bioavailability and an increase in CBD's therapeutic effects.Here we report on a facile and cost-effective precipitation method for fast CBD nanonization.The characterization of the particle size in various suspensions was determined by dynamic light scattering (DLS), while scanning electron microscopy (SEM) analysis was performed to obtain the size and morphology of the dried CBD particles.The influence of the synthesis parameters (type and concentration of solvents and surfactants) on the size of the CBD particles in suspension were evaluated.By addition of the surfactants, the agglomeration of CBD nanoparticles (NPs) in suspension was prevented and the suspensions maintained stability for up to 9 months.
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Štukelj et al. (2019) studied this question.
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