What question did this study set out to answer?

To review the mechanisms and functional implications of phenotypic and morphological plasticity in astrocytes during brain development, physiological signaling, and neuronal degeneration.

June 1, 1994Glia

Plasticity of astrocytes

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Authors

YSYanping ShaoNational University of Defense Technology KMKen D. McCarthyUniversity of North Carolina at Chapel Hill

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Implication

Narrative review reveals extensive phenotypic and morphological plasticity in brain astrocytes, suggesting active modulation of neuronal environments throughout life.

Key Points

To review the mechanisms and functional implications of phenotypic and morphological plasticity in astrocytes during brain development, physiological signaling, and neuronal degeneration.
Narrative synthesis of experimental evidence examining receptor expression, morphological adaptations, and neurotransmitter signaling in mammalian astrocytes.
Glial receptor expression undergoes dynamic developmental shifts in response to both cell-intrinsic cues and extrinsic neuronal signals.
Neuronal degeneration promotes the up-regulation of beta-adrenergic receptors, which modulates reactive astrocyte behavior in the adult brain.
Neurotransmitters including norepinephrine and glutamate reciprocally regulate astrocyte morphology, influencing the volume of the extracellular space and surrounding neuronal activity.

Cite This Study

Shao et al. (1994) studied this question.

synapsesocial.com/papers/6aa1021996c8fbb7e31a0702 https://doi.org/10.1002/glia.440110209

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Implication

Narrative review reveals extensive phenotypic and morphological plasticity in brain astrocytes, suggesting active modulation of neuronal environments throughout life.

Plasticity of astrocytes

Discussion

Member takes

Implication

Key Points

Cite This Study

Plasticity of astrocytes

Discussion

Member takes

Implication

Key Points

Cite This Study

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