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The simian immunodeficiency viruses (SIVs) were initially identified on the basis of antibody cross-reactivity with human immunodeficiency virus type 1 (HIV-1)1. Serum samples from macaque monkeys from Asia with AIDS-like diseases were found to have antibodies that reacted with HIV-1 antigens. The reactivity was most pronounced for the viral core antigens and less evident for the type-specific viral envelope antigens. HIV type 2 (HIV-2) was subsequently identified in West African prostitutes on the basis of a serologic antibody profile that more closely resembled the profile of macaque SIV than that of HIV-12.Seroepidemiologic studies reveal that wild African . . .
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Max Essex (1994) studied this question.
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