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April 30, 2020HeartOpen Access

Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis

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Why the study?

Does acute myocardial injury predict adverse clinical outcomes in patients with COVID-19?

Population

101 patients with COVID-19 presenting to two designated treatment centres in Sichuan, China, average age 49…

Comparison

Acute myocardial injury vs Patients without acute myocardial injury

Design

Cohort

Key result

Acute myocardial injury in COVID-19 patients was associated with significantly higher rates of ICU admission (62.5% vs 24.7%, p=0.003) and mechanical ventilation (43.5% vs 4.7%, p<0.001).

Authors

JWJiafu WeiFHFang‐Yang HuangTXTian‐Yuan Xiong

Discussion

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Member takes

Overview

Acute myocardial injury was associated with higher ICU admission, ventilation needs and mortality in COVID-19; leaves open whether routine troponin monitoring improves outcomes.

Study Design

Type

Cohort (n=101)

Multicenter

Yes

Structured PICO

Does acute myocardial injury predict adverse clinical outcomes in patients with COVID-19?

P
Population
101 patients with COVID-19 presenting to two treatment centers in Sichuan, China.
E
Exposure
Acute myocardial injury (defined by high-sensitivity troponin T greater than the normal upper limit)
C
Comparator
Patients without acute myocardial injury
O
Outcome
Death, admission to an intensive care unit (ICU), need for mechanical ventilation, treatment with vasoactive agents, and classification of disease severityhard clinical

Main Result

Absolute Event Rate: 62.5% vs 24.7%

p-value: p=0.003

Acute myocardial injury is common in COVID-19 patients and is strongly associated with increased disease severity and adverse clinical outcomes such as ICU admission and mechanical ventilation.

Cite This Study

Wei et al. (2020) conducted a cohort in COVID-19 (n=101). Acute myocardial injury vs. No acute myocardial injury was evaluated on ICU admission (p=0.003). Acute myocardial injury in COVID-19 patients was associated with significantly higher rates of ICU admission (62.5% vs 24.7%, p=0.003) and mechanical ventilation (43.5% vs 4.7%, p<0.001).

synapsesocial.com/papers/6aa1027c8eabfe21f24f8398https://doi.org/10.1136/heartjnl-2020-317007
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